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Milk Thistle 

The reason that milk thistle is often used as a hangover cure is that it has been traditionally used to cleanse and detox the body.

Silymarin, which is the main bioactive component of milk thistle, is a powerful antioxidant. This means it prevents the damage caused by excess free radicals in the body.

Alcohol consumption increases the amount of free radicals circulating around your cells, milk thistle assists detoxing these free radicals from the body. 

What’s more, milk thistle has anti-inflammatory properties, which can help calm the inflammation caused in your stomach, head and other areas of the body by alcohol.

 

Prickly Pear

Prickly pear has anti-inflammatory properties that can reduce the symptoms from alcohol consumption, especially nausea. A study done by Tulane Health Sciences Center had 55 young adults take 1600 IU of OFI (Opuntia ficus indica) before drinking a variety of liquor for several hours. They recorded biosamples and observed symptoms on a graded index.  

The study found three symptoms reduced by an average of 2.7 points (on a scale of 0-6).

• Nausea
• Dry mouth
• Anorexia (loss of appetite)

The test subjects also had lower levels of C-reactive protein, which is produced by the liver and linked to inflammation.

All of these results indicated prickly pear extract is effective in reducing the effects of alcohol consumption.  

Organic Prickly Pear Extract can help protect against the potential long-term effects of alcohol. As your body tries to break down alcohol, it inevitably produces free-radicals that can damage your cells. OPI acts as an antioxidant, protecting proteins and lipids from damage while alcohol is being broken down. It’s also been known to support:

• Digestive Health
• Immunity Support

The anti-inflammatory effects of prickly pear cactus are also well known.

Not surprisingly, athletes have turned to prickly pear cactus to get more energy in the gym, to reduce post-exercise muscle soreness, to speed recovery and to reduce the chances of getting DOMS (delayed onset muscle soreness).  Prickly pear extract has proven remarkably useful as an ergogenic recovery aide.

 

N-Acetyl-Cyseine (NAC)

N-acetyl cysteine comes from the amino acid L-cysteine. 

Consuming adequate cysteine and NAC is important for a variety of health reasons — including replenishing the most powerful antioxidant in your body, glutathione. These amino acids also help with chronic respiratory conditions, Detoxification, and brain health.

Glutathione is one of the body’s most important antioxidants, which helps neutralize free radicals that can damage cells and tissues in your body.

When ethanol hits the liver, it’s metabolized into the toxin acetaldehyde—one of the main culprits of hangovers as well as liver damage. So, a good hangover remedy is one that would decrease the amount of time that the body is exposed to acetaldehyde. N-acetylcysteine boosts the production of glutathione, which breaks down acetaldehyde.

It’s essential for immune health and fighting cellular damage. Some researchers believe it may even contribute to longevity.

 

Dihydromyricatin (DHM)

DHM has long been used in Eastern medicine to benefit the liver and brain. Found in a Japanese raisin tree, which produces Hovenia Dulsis extract, this supplement helps your liver metabolize alcohol more quickly and blocks alcohol from accessing the GABA receptors in the brain.

To better understand what the drug does inside the body, the scientists fed 36 mice a daily diet of alcohol for two months, gradually increasing doses to 30% of their total food intake for an average of 39.4 g/kg of ethanol per day per mouse. Then, they assessed their livers for injury and markers of stress.

Among other significant effects, the scientists found that DHM:

• Triggered the liver to produce more ethanol-gobbling enzymes, including alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH).
• Boosted the efficiency of ADH and ALDH, enabling the enzymes to convert ethanol into simpler forms the body can eliminate easier.
• Reduced lipid (fat) accumulation in liver tissue. Heavy doses of alcohol can negatively affect the liver’s metabolism, leading to an accumulation of fat, increased stress and the eventual progression to liver diseases such as cirrhosis.
• Reduced inflammatory agents, called cytokines. Excessive alcohol leads to the release of cytokines in the liver, which contributes to cellular damage to the liver and other organs.

“In total, these findings support the utility of DHM as a dietary supplement to reduce ethanol-induced liver injury via changes in lipid metabolism, enhancement of ethanol metabolism and suppressing inflammation responses to promote liver health,” the study said. “This line of research suggests that DHM acts on multiple pathways to promote liver health and counteract ethanol injury.”

 

Magnesium

Magnesium is an important anti-inflammatory mineral that many people are deficient in and it is shown that alcohol depletes magnesium in the body.

Magnesium supports the alcohol dehydrogenase enzyme that breaks down alcohol and eliminates it from the body.

Alcohol depletes a broad range of vitamins, amino acids, fatty acids, enzymes, proteins and minerals from your body. The kingpin to this depletion is magnesium which is the anti-stress mineral that most people with a hangover are deficient in. This mineral regulates over 800 enzyme actions in the body.

Nutritional magnesium prevents platelet aggregation, which helps to avoid the thickened blood and tiny clots that can cause blood vessel spasms and the pain of a tension headache and hangover.

Magnesium relaxes the head and neck muscle tension that makes a hangover worse.

 

B Vitamins

Drinking alcohol definitely depletes vitamins in the body and B-vitamins are responsible for many metabolic processes of the body — the liver detox pathways rely on B’s to detox effectively.

For starters, alcohol is a diuretic, so you lose a lot of vitamins and nutrients while you are drinking. The most heralded is B12 (also called cobalamin), which performs a key role in the functioning of the brain and nervous system. 

In a study, a supplement containing vitamins B-1 and B-6 was shown to help reduce hangover symptoms. In this 2012 study, subjects were sent a supplement and were encouraged to take it before and after drinking alcohol. Of the subjects who completed the study, 88 percent reported a reduction in hangover symptoms.

Work published in the Quarterly Journal of Studies on Alcohol studied the effect of a type of Vitamin B-6 known as pyritinol on the development of hangovers.1 Subjects received pyritinol or a placebo before, during, and after a party in which they drank alcohol. Those who received the pyritinol reported fewer symptoms of a hangover the next morning than those receiving a placebo. However, this work was published in 1973 and more up-to-date research is required to confirm its benefits.

At Alpha Mind Labs we have spent 2 years formulating and sourcing only the most potent, well-studied and clinical trial-backed compounds combined with the most synergetic composition to product the most advanced nootropic supplement for brain optimisation.

All our compounds have received clinical trials in double-blind placebo tests and rigorous quality assurance testing to establish safety and efficacy before formulation.

Produced in our state of the art FDA approved laboratory in the USA with GMP, ASI and USDA certification, all compounds are third party tested, heavy metal tested and go through rigorous quality assurance testing to ensure only the highest quality ingredients are used.

At Alpha Mind Labs we have spent 2 years formulating and sourcing only the most potent, well-studied and clinical trial-backed compounds combined with the most synergetic composition to product the most advanced nootropic supplement for brain optimisation.

All our compounds have received clinical trials in double-blind placebo tests and rigorous quality assurance testing to establish safety and efficacy before formulation.

Produced in our state of the art FDA approved laboratory in the USA with GMP, ASI and USDA certification, all compounds are third party tested, heavy metal tested and go through rigorous quality assurance testing to ensure only the highest quality ingredients are used.